肠道菌群的变化是否会引发精神障碍？哪些细菌会通过脑肠轴影响人的情绪？2022年2月3日，澳大利亚Baker Heart and Diabetes Institute的Guillaume Méric与Michael Inouye合作（第一作者为覃友文）在Nature Genetics上发表了文章Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort，揭示了特定肠道细菌是抑郁症的潜在致病因子【1】。
1. Qin, Y., et al., Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort. Nature Genetics, 2022.
2. Maes, M., M. Kubera, and J.-C. Leunis, The gut-brAIn barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro endocrinology letters, 2008. 29 1: p. 117-24.
3. Yang, J., et al., Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders. Science Advances, 2020. 6(49): p. eaba8555.
4. Wyres, K.L., M.M.C. Lam, and K.E. Holt, Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol, 2020. 18(6): p. 344-359.
5. Ma, Y., et al., Proposal for reunification of the genus Raoultella with the genus Klebsiella and reclassification of Raoultella electrica as Klebsiella electrica comb. nov. Research in Microbiology, 2021. 172(6): p. 103851.
6. Jiang, H., et al., Altered fecal microbiota composition in patients with major depressive disorder. Brain, Behavior, and Immunity, 2015. 48: p. 186-194. 转载须知【非原创文章】本文著作权归文章作者所有，欢迎个人转发分享，未经允许禁止转载，作者拥有所有法定权利，违者必究。
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