▲突变小鼠与人类表现出类似的生理衰老变化(图片来源:参考资料[1])
论文指出,这项研究分析了营养信号增加的小鼠衰老症状的决定因素,结果表明作用于慢性炎症可作为控制健康状况恶化的潜在治疗方向。此外,这项研究将营养信号与哺乳动物寿命联系起来,表明能量限制作为一种有效的干预措施,通过对mTORC1信号通路的调控,起到延长哺乳动物健康寿命的作用。
参考资料:[1] Ortega-Molina, A., Lebrero-Fernández, C., Sanz, A. et al. A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00635-x[2] Aging speeds up and lifetime becomes shorter in animals whose cells ‘believe’ to have too many nutrients, despite following a normal diet. Retrieved on Jun. 8th from https://www.eurekalert.org/news-releases/1047137